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Home > Products >  Antiepileptic and anticonvulsant Gabapentin Neurontin hcl Powder CAS 60142-96-3

Antiepileptic and anticonvulsant Gabapentin Neurontin hcl Powder CAS 60142-96-3 CAS NO.60142-96-3

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  • FOB Price: USD: 70.00-100.00 /Kilogram Get Latest Price
  • Min.Order: 10 Gram
  • Payment Terms: L/C,D/P,T/T,Western Union,MoneyGram
  • Available Specifications:

    1(1-10)Kilogram1(11-50)Kilogram2(51-100)Kilogram

  • Product Details

Keywords

  • Gabapetin
  • Gabapentin
  • 60142-96-3

Quick Details

  • ProName: Antiepileptic and anticonvulsant Gabap...
  • CasNo: 60142-96-3
  • Molecular Formula: C9H17NO2
  • Appearance: white
  • Application: Gabapetin Neurontin
  • DeliveryTime: within 2 days after receiving your pre...
  • PackAge: Foil Bag or as customer's request
  • Port: Tianjin Port,Shanghai,or as the custom...
  • ProductionCapacity: 200 Metric Ton/Month
  • Purity: 99%
  • Storage: Store in cool & dry ,ventilated
  • Transportation: DHL TNT UPS FEDEX EMS
  • LimitNum: 10 Gram
  • Moisture Content: <0.001
  • Impurity: <0.001
  • package: aluminum foil bag or as customer's req...
  • Density: 1.1±0.1 g/cm3
  • Molecular weight: 171.237
  • Molecular Formula: C9H17NO2
  • CAS: 60142-96-3

Superiority


Packing&Shipping

Price negotiable according to how many do you need
Payment Term TT/West Union /Bitcoin/ Money Gram
Delivery Time normally 5-10 days by express
Shipping way                 Express(EMS,DHL,TNT,FedEX;HKDHL;EUB) Door to Door
Transport by air for large quantity.
Shipping Time Most countries caan arrived within 3-10 days                                                        

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FAQ

Q1: Can i get some samples

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).

Q3: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What’s your MOQ
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery leadtime
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Details

Product Information

Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.IC50 Value: 140 nM (α2δ subunit of calcium channel) [1]Target: Calcium Channelin vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release [2]. A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM) [3].in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody [4].Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified [5].Clinical trial: N/A

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